Friedrich Miescher Institute for Biomedical Research
Maulbeerstrasse 66
4058 Basel, Switzerland
Email: mohamed.bentires-alj@fmi.ch
Secretary: Dawn Hammond
Phone: +41 61 697 66 51
Protein tyrosine phosphatases in cancer and metastasis
Protein tyrosine phosphorylation plays a vital regulatory role in many biological processes including proliferation, differentiation, apoptosis and migration. Dysregulation of the signalling pathways controlling these processes can lead to diseases such as autoimmunity and cancer. Protein-tyrosine kinases (PTKs) and protein-tyrosine phosphatases (PTPs) mediate the phosphorylation and dephosphorylation of proteins on tyrosine residues, respectively. Although the roles of several PTKs in breast cancer have been elucidated, specific roles for PTPs remain elusive. We examine the possible involvement of PTPs in breast cancer development and metastasis. Studies of the role of PTPs in oncogenic signalling may open new avenues for the design of targeted therapies for breast cancer.
